The NeuralGlider™ System

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Reduces insertion trauma and improves placement accuracy of penetrating neural implants in pre-clinical studies.

Actuated Medical, Inc. designed the NeuralGlider-Cortical System to maximize the quality of chronic neural implant recordings in pre-clinical neuroscience studies. NeuralGlider applies micron-scale, ultrasonic vibration to microwire arrays during insertion to reduce the force required to penetrate the brain surface. The reduced insertion force facilitates slow (0.1 mm/s), accurate array insertions while minimizing displacement/dimpling of the cortical surface, preserving the integrity of the underlying neural tissue.

Minimizes Insertion Force and Tissue Dimpling

Ultrasonic vibration of microwire arrays during insertions with NeuralGlider significantly reduced penetration force in an agar brain model, and ex vivo model 1 and model 2 cortex (reductions in force = 86.3%, 76.5% and 62.7%, respectively). The reduction of force correlates to a 70 - 80% reduction in cortical surface displacement/dimple during array insertion, for all tissues. * p < 0.0001; error bars = standard error of the mean. All data were normalized to the non-vibrated/control insertion average for each tissue.

Key Advantages

  • Reduced insertion force and tissue dimpling yielding less insertion damage and neuron loss.
  • Integrated software for control of insertion velocity and depth.
  • Improved insertion of fixed microwire arrays.

See How It Works

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These works are/were partially supported by the Defense Advanced Research Projects Agency (DARPA) Contract No. HR0011-16-C-0094. Approved for Public Release, Distribution Unlimited. The views, opinions, and/or findings contained in this work are those of Actuated Medical, Inc. and should not be construed as an official government position, policy, or decision unless so designated by other documentation.

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